We stayed in the beautiful and very modern Room Mate Aitana. Getting from the airport was easy with very regular direct trains and the hotel was less than a 10 minute walk from the station.
No trip to Amsterdam is complete without a visit to Anne Frank's House which I found fascinating but be sure to book it well in advance. The Van Gogh Museum is definitely worth a visit too. We went on a canal boat where we saw the city from a unique perspective and booked a day trip that took us into the beautiful Dutch countryside where we passed windmills and stunning fields full of the most colourful tulips.
Holland is a wonderful country, very safe, public transport is excellent and English is widely spoken. Amsterdam can be pricey at weekends so it's worth considering a mid-week break. Amsterdam can be easily combined with a stay or a day trip to Antwerp, Delft, Rotterdam, Gouda or Bruges.